Murine Anti-Factor X
Factor X (Mr 59,000) is a vitamin K-dependent plasma protein zymogen that plays a central role as the substrate for both the intrinsic (factor VIIa, tissue factor) and extrinsic (factor IXa, factor VIIIa) pathways. In the presence of cofactor factor Va, phospholipid, and Ca2+, activated factor X cleaves two peptide bonds in prothrombin to form thrombin. GMA-529 (also known as α-HFX-27) binds human factor X and Xa in solid-phase ELISA and Western blot. GMA-529 prolonged FX-dependent clotting time, and activated partial thromboplastin time of normal plasma, and showed inhibition of thrombin generation.1
- Species Reactivity:Human
- Specificity:Factor X/Xa
- Immunogen:Human Factor X
- ELISA:Binds immobilized human factor X and factor Xa. Does not bind mouse FX.
- Immunoblotting:Binds human factor X and Xa under non-reduced conditions. Does not blot reduced FX/Xa.
- Inhibition:Inhibits thrombin generation, prolongs clotting time1.
$265.00 – $660.00