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GMA-054

You are here: Home / Human Plasma Antigens / GMA-054
Return to Protein C Summary Page

Murine Anti-Protein C

Clone GMA-054

Background

Thrombin, in the presence of thrombomodulin, cleaves protein C giving the active protease activated protein C (APC). APC plays a regulatory role in coagulation by functioning as an anticoagulant by proteolytic inactivation of Factors V (Va) and VIII (VIIIa). Protein C (Mr 62,000) consists of a heavy chain (Mr 41,000) disulfide bonded to a Gla-containing light chain (Mr 21,000) which contains two EGF domains. GMA-054 is calcium dependent, and recognizes the activation region of Protein C. It can be used in western blot and ELISA applications. GMA-054 does not recognize activated Protein C and inhibits activation of Protein C by thrombin-thrombomodulin.

More Information

Product Datasheet as PDF

Description

  • Species Reactivity:
    Human, Pig, Baboon, Canine
  • Source:
    Murine
  • Specificity:
    activation region of Protein C
  • Immunogen:
    Human Protein C
  • Isotype:
    IgG1

Application

  • ELISA:
    Binds immobilized human protein C only in the presence of calcium.
  • Immunoblotting:
    Binds protein C under reduced and non-reduced conditions.
  • Inhibition:
    Inhibits activation of Protein C by thrombin-thrombomodulin.

Data

Text_2

Antibody References

  1. Esmon, C. (1993). U.S. Patent No. 5,202,253.

$265.00 – $660.00

Buy: GMA-054
0.5 mg/$660.00 0.1 mg/$265.00
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