Murine Anti-Protein C
Thrombin, in the presence of thrombomodulin, cleaves protein C giving the active protease activated protein C (APC). APC plays a regulatory role in coagulation by functioning as an anticoagulant by proteolytic inactivation of Factors V (Va) and VIII (VIIIa). Protein C (Mr 62,000) consists of a heavy chain (Mr 41,000) disulfide bonded to a Gla-containing light chain (Mr 21,000) which contains two EGF domains. GMA-054 is calcium dependent, and recognizes the activation region of Protein C. It can be used in western blot and ELISA applications. GMA-054 does not recognize activated Protein C and inhibits activation of Protein C by thrombin-thrombomodulin.
- Species Reactivity:Human, Pig, Baboon, Canine
- Specificity:activation region of Protein C
- Immunogen:Human Protein C
- ELISA:Binds immobilized human protein C only in the presence of calcium.
- Immunoblotting:Binds protein C under reduced and non-reduced conditions.
- Inhibition:Inhibits activation of Protein C by thrombin-thrombomodulin.
- Esmon, C. (1993). U.S. Patent No. 5,202,253.
$265.00 – $660.00